SC16
A Study of Insulin Resistance in Multiple Sclerosis Subjects and Healthy Controls
Objectives: Determine incidence of insulin resistance in MS subjects compared to healthy controls using oral glucose tolerance test (OGTT).
Methods: Recruitment ongoing for 50 subjects (25 each): age 18 -64, non-obese, fasting blood glucose (BG) < 126, and without diabetes mellitus. OGTT completed with BG measured at 30, 60, and 120 minutes. MS functional composite, 6-minute and 2-minute walks, and health and quality of life surveys collected. Community ambulation measured with 7-day accelerometer.
Results: Preliminary analysis of first 28 subjects (14 MS/14 controls) similar in age, gender & BMI. At all OGTT time points MS subjects demonstrate statistically higher mean BG levels; MS subjects 120-min BG compared to controls [mean (25th, 75th), 114 (99, 132) vs. 93 (92, 103), p-value = 0.037]. Within the MS cohort, time from MS-symptom onset was significantly correlated with 2-hr BG (Rho = 0.464, p-value = 0.01). There was statistically significant differences in total daily accelerometer counts, 6-minute and 2-minute test distance between MS and controls; however, there was no significant correlation between these measures and 120-min BG levels. Further analyses are ongoing.
Conclusions: Preliminary analyses demonstrate that compared with controls, MS subjects have higher BG level with OGTT at 30, 60, and 120 mins. While MS subjects have reduced measured distance on timed-walk test and in the community, this is not correlated to OGTT results. One interpretation is that subject’s fitness level is not the explanation for OGTT findings, but rather may be MS disease specific. Notably, OGTT results did significantly correlate to time since MS-symptom onset. This work is in progress. Complete enrollment and data analysis will be ready for meeting presentation.
Study Supported by: NIH NINDS K23NS062898 and ziMS Foundation.