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70.697 2.852 m
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71.692 3.937 m
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h
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h
81.662 2.107 m
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h
93.346 0.596 m
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h
95.566 0.881 m
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h
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h
99.549 -1.085 m
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h
100.441 2.107 m
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h
107.915 2.26 m
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108.469 1.299 108.616 1.337 108.709 1.37 c
h
110.306 0.172 m
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h
117.646 0.172 m
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122.712 2.315 122.571 2.543 122.374 2.692 c
124.064 2.26 m
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123.934 2.114 123.992 2.207 124.064 2.26 c
124.858 1.219 m
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124.539 0.512 124.414 0.467 124.283 0.467 c
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123.919 0.66 123.881 0.751 123.881 0.857 c
123.881 0.964 123.928 1.053 124.023 1.123 c
124.085 1.166 124.216 1.209 124.417 1.254 c
124.618 1.299 124.765 1.337 124.858 1.37 c
h
128.774 1.772 m
128.774 1.993 128.761 2.162 128.734 2.28 c
128.708 2.398 128.66 2.504 128.593 2.597 c
128.525 2.69 128.425 2.767 128.292 2.827 c
128.16 2.887 128.014 2.917 127.854 2.917 c
127.491 2.917 127.19 2.755 126.952 2.433 c
126.952 2.852 l
126.279 2.852 l
126.279 0 l
127.003 0 l
127.003 1.292 l
127.003 1.61 127.022 1.829 127.059 1.947 c
127.096 2.065 127.164 2.16 127.264 2.232 c
127.363 2.303 127.476 2.339 127.601 2.339 c
127.699 2.339 127.783 2.314 127.853 2.264 c
127.922 2.214 127.973 2.143 128.003 2.053 c
128.034 1.963 128.05 1.763 128.05 1.456 c
128.05 0 l
128.774 0 l
h
132.939 2.692 m
132.742 2.842 132.477 2.917 132.144 2.917 c
131.737 2.917 131.414 2.785 131.175 2.523 c
130.936 2.261 130.816 1.894 130.816 1.423 c
130.816 0.958 130.935 0.594 131.173 0.33 c
131.411 0.067 131.731 -0.064 132.131 -0.064 c
132.483 -0.064 132.764 0.022 132.974 0.196 c
133.184 0.37 133.326 0.627 133.399 0.967 c
132.688 1.093 l
132.652 0.894 132.59 0.754 132.502 0.673 c
132.415 0.591 132.302 0.551 132.165 0.551 c
131.981 0.551 131.834 0.62 131.725 0.76 c
131.616 0.9 131.561 1.139 131.561 1.477 c
131.561 1.781 131.615 1.998 131.722 2.128 c
131.83 2.258 131.974 2.323 132.154 2.323 c
132.29 2.323 132.4 2.285 132.486 2.21 c
132.571 2.135 132.625 2.023 132.649 1.875 c
133.363 2.009 l
133.277 2.315 133.136 2.543 132.939 2.692 c
133.923 0.632 m
134.041 0.404 134.215 0.231 134.442 0.113 c
134.67 -0.005 134.909 -0.064 135.16 -0.064 c
135.566 -0.064 135.902 0.077 136.17 0.361 c
136.437 0.645 136.571 1.003 136.571 1.434 c
136.571 1.862 136.438 2.216 136.174 2.496 c
135.909 2.776 135.569 2.917 135.155 2.917 c
134.887 2.917 134.644 2.855 134.427 2.731 c
134.209 2.608 134.041 2.429 133.923 2.194 c
133.804 1.96 133.745 1.717 133.745 1.466 c
133.745 1.139 133.804 0.861 133.923 0.632 c
134.681 2.076 m
134.81 2.226 134.969 2.302 135.158 2.302 c
135.347 2.302 135.505 2.226 135.633 2.076 c
135.762 1.926 135.826 1.711 135.826 1.431 c
135.826 1.145 135.762 0.927 135.633 0.776 c
135.505 0.626 135.347 0.551 135.158 0.551 c
134.969 0.551 134.81 0.626 134.681 0.776 c
134.552 0.927 134.487 1.143 134.487 1.426 c
134.487 1.709 134.552 1.926 134.681 2.076 c
139.649 3.937 m
138.924 3.937 l
138.924 2.519 l
138.701 2.784 138.436 2.917 138.13 2.917 c
137.797 2.917 137.521 2.791 137.303 2.539 c
137.085 2.288 136.975 1.92 136.975 1.437 c
136.975 0.964 137.087 0.596 137.312 0.332 c
137.536 0.068 137.805 -0.064 138.12 -0.064 c
138.275 -0.064 138.428 -0.025 138.58 0.055 c
138.732 0.135 138.864 0.256 138.976 0.419 c
138.976 0 l
139.649 0 l
h
137.889 2.126 m
138.005 2.268 138.149 2.339 138.321 2.339 c
138.498 2.339 138.643 2.267 138.757 2.123 c
138.87 1.979 138.927 1.743 138.927 1.415 c
138.927 1.122 138.869 0.901 138.752 0.753 c
138.635 0.606 138.493 0.532 138.326 0.532 c
138.117 0.532 137.953 0.63 137.836 0.827 c
137.756 0.963 137.715 1.183 137.715 1.488 c
137.715 1.771 137.773 1.983 137.889 2.126 c
141.773 0.596 m
141.696 0.532 141.601 0.5 141.487 0.5 c
141.32 0.5 141.181 0.562 141.069 0.686 c
140.958 0.811 140.899 0.985 140.894 1.208 c
142.709 1.208 l
142.719 1.787 142.607 2.216 142.371 2.496 c
142.136 2.776 141.815 2.917 141.407 2.917 c
141.044 2.917 140.745 2.783 140.507 2.515 c
140.27 2.247 140.152 1.877 140.152 1.405 c
140.152 1.009 140.242 0.681 140.422 0.422 c
140.651 0.098 141.003 -0.064 141.479 -0.064 c
141.78 -0.064 142.031 0.008 142.231 0.152 c
142.431 0.296 142.578 0.506 142.67 0.781 c
141.949 0.908 l
141.909 0.764 141.851 0.661 141.773 0.596 c
140.907 1.67 m
140.905 1.876 140.956 2.039 141.059 2.159 c
141.162 2.279 141.293 2.339 141.451 2.339 c
141.599 2.339 141.724 2.282 141.827 2.169 c
141.93 2.055 141.985 1.889 141.99 1.67 c
h
144.024 0.755 -0.724 -0.755 re
144.024 0 m
f
Q
Q
BT
/GS0 gs
18 0 0 18 178.666 809.1052 Tm
(Use of a Delphi Process to Gain Consensus on Effective Management of Gas\
trointestinal )Tj
42.509 0 Td
( )Tj
-37.015 -1.2 Td
[(Side Effects )37.2(Associated W)8.6(ith Delayed-Release Dimethyl Fumarate)]TJ
13 0 0 13 236.0078 768.0052 Tm
[(Phillips JT)111.9(,)]TJ
7.579 0 0 7.579 303.1913 772.3342 Tm
(1)Tj
-0.037 Tw 13 0 0 13 307.4064 768.0052 Tm
[( )-36.8(Erwin )0.6(A,)]TJ
0 Tw 7.579 0 0 7.579 362.5422 772.3342 Tm
(2)Tj
-0.037 Tw 13 0 0 13 366.7572 768.0052 Tm
[( Agrella )-37(S,)]TJ
0 Tw 7.579 0 0 7.579 429.8529 772.3342 Tm
(3)Tj
13 0 0 13 434.068 768.0052 Tm
[( Kremenc)-0.6(hutzky M,)]TJ
7.579 0 0 7.579 552.5406 772.3342 Tm
(4)Tj
13 0 0 13 556.7557 768.0052 Tm
( Kramer J,)Tj
7.579 0 0 7.579 620.3466 772.3342 Tm
(5)Tj
13 0 0 13 624.5616 768.0052 Tm
( Kendter J,)Tj
7.579 0 0 7.579 691.7452 772.3342 Tm
(6)Tj
-0.037 Tw 13 0 0 13 695.9603 768.0052 Tm
[( Abourjaily )-36.6(H,)]TJ
0 Tw 7.579 0 0 7.579 779.2669 772.3342 Tm
(7)Tj
13 0 0 13 783.482 768.0052 Tm
( Rana J,)Tj
7.579 0 0 7.579 833.3365 772.3342 Tm
(7)Tj
13 0 0 13 837.5516 768.0052 Tm
( Fox R)Tj
7.579 0 0 7.579 877.2752 772.3342 Tm
(8)Tj
6.413 0 0 6.413 139.3979 755.1683 Tm
(1)Tj
11 0 0 11 142.9645 751.5052 Tm
(Baylor Institute for Immunology Research, Dallas, TX, USA; )Tj
6.413 0 0 6.413 456.5289 755.1683 Tm
(2)Tj
11 0 0 11 460.0955 751.5052 Tm
(The NeuroMedical Center Clinic, Baton Rouge, LA, USA; )Tj
6.413 0 0 6.413 757.1224 755.1683 Tm
(3)Tj
11 0 0 11 760.689 751.5052 Tm
[(Multiple Sclerosis Clinic of Central T)75.8(exas, )]TJ
( )Tj
-56.262 -1.091 Td
(Round Rock, TX, USA; )Tj
6.413 0 0 6.413 262.8043 743.1683 Tm
(4)Tj
11 0 0 11 266.3708 739.5052 Tm
[(W)18.2(estern University and London Health Sciences Centre, London, ON, Canada;\
)]TJ
6.413 0 0 6.413 678.7366 743.1683 Tm
(5)Tj
11 0 0 11 682.3032 739.5052 Tm
(Center For Neurological Disorders, Milwaukee, WI, USA; )Tj
26.95 0 Td
( )Tj
6.413 0 0 6.413 203.7919 731.1683 Tm
(6)Tj
11 0 0 11 207.3585 727.5052 Tm
[(Biogen, W)18.9(eston, MA, USA; )]TJ
6.413 0 0 6.413 349.5421 731.1683 Tm
(7)Tj
11 0 0 11 353.1087 727.5052 Tm
(Biogen, Cambridge, MA, USA; )Tj
6.413 0 0 6.413 513.2264 731.1683 Tm
(8)Tj
11 0 0 11 516.793 727.5052 Tm
(Mellen Center for Multiple Sclerosis at Cleveland Clinic, Cleveland, OH,\
USA)Tj
18 0 0 18 42.3868 809.1052 Tm
(DX67)Tj
ET
q
0 0 1190.549 841.889 re
W n
/CS0 CS 1 SCN
19.875 w 10 M
q 1 0 0 1 36 686.1531 cm
0 0 m
231.84 0 l
S
Q
q 1 0 0 1 36 351.3532 cm
0 0 m
231.84 0 l
S
Q
Q
BT
12 0 0 12 105.9239 682.0506 Tm
(INTRODUCTION)Tj
/CS0 cs 1 scn
8.5 0 0 8.5 36 664.6506 Tm
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
1.059 0 Td
(Delayed-release dimethyl fumarate \(DMF; also known )Tj
0 -1.2 TD
(as gastro-resistant DMF\) 240 mg twice daily \(BID\) is an )Tj
-0.001 Tw 0 -1.2 TD
[(oral therapy indicated )0.7(for the treatment of )0.5(patients with )]TJ
0 Tw 0 -1.2 TD
(relapsing multiple sclerosis \(MS\).)Tj
/CS0 cs 1 scn
/GS0 gs
-0.025 Tc 0.025 Tw -1.059 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
/C2_0 1 Tf
1.059 0 Td
[<002C005100030057004B004800030033004B0044005600480003001600030056005700580047004C00480056000F000300270030002900030056004C004A0051004C00BF0046004400510057004F005C0003005500480047005800460048004700030046004F004C0051004C00460044004F>-24.8<0003>]TJ
/TT0 1 Tf
0 Tc 0 Tw T*
(and magnetic resonance imaging disease activity )Tj
/C2_0 1 Tf
T*
<00590056001100030053004F00440046004800450052000F00030044005100470003004B00440047000300440051000300440046004600480053005700440045004F0048000300560044004900480057005C000300530055005200BF004F004800110003>Tj
/TT0 1 Tf
T*
(Gastrointestinal \(GI\) events \(e.g., nausea, vomiting, )Tj
-0.025 Tc T*
[(abdominal pain, diarrhea\) were more common in patients)-25.1( )]TJ
0 Tc T*
(treated with DMF than placebo \(40% vs. 31%\).)Tj
4.9555 0 0 4.9555 229.2068 571.1811 Tm
(1-3)Tj
/CS0 cs 1 scn
/GS0 gs
/Span<>> BDC
8.5 0 0 8.5 53.3273 555.9906 Tm
( )Tj
EMC
-0.556 0 Td
(\226)Tj
0 0 0 1 k
/GS1 gs
1.056 0 Td
(Study protocols permitted measures to optimize )Tj
0.003 -1.2 Td
[(DMF tolerability)74.7(, including taking medication with )]TJ
T*
(food, dose reduction, and use of symptomatic )Tj
T*
(therapies.)Tj
/CS0 cs 1 scn
/GS0 gs
/Span<>> BDC
-0.528 -1.454 Td
( )Tj
EMC
-0.531 0 Td
(\226)Tj
0 0 0 1 k
/GS1 gs
-0.025 Tc 1.006 0 Td
[(GI events were mild or moderate in severity and the)-25.2( )]TJ
/C2_0 1 Tf
-0.005 Tc 0.005 Tw 0.053 -1.2 Td
[<004C>20.2<0051>20.1<0046>19.9<004C>20.1<0047>20.2<0048>19.8<0051>20.2<0046>19.8<0048>19.9<0003>20.1<004700480046005500480044005600480047000300560058004500560057004400510057004C0044004F004F005C00030044004900570048005500030057004B0048000300BF005500560057>-5<0003>]TJ
/TT0 1 Tf
0 Tw T*
(month of treatment.)Tj
/CS0 cs 1 scn
/GS0 gs
0 Tc -2.541 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
1.059 0 Td
[(A)36.9( Delphi consensus-building method was used to gain )]TJ
T*
(further insights into GI events associated with DMF in )Tj
T*
(the real world:)Tj
/CS0 cs 1 scn
/GS0 gs
/Span<>> BDC
0.955 -1.454 Td
( )Tj
EMC
-0.531 0 Td
(\226)Tj
0 0 0 1 k
/GS1 gs
/C2_0 1 Tf
-0.025 Tc 0.025 Tw 1.006 0 Td
[<0026004F00440055004C00BF004600440057004C0052005100030052004900030057004B00480003004C00510046004C00470048005100460048000F000300490055004800540058004800510046005C>74<000F0003004400510047000300470058005500440057004C00520051>-24.8<0003>]TJ
/TT0 1 Tf
-0.01 Tc 0 Tw 0.053 -1.2 Td
(of DMF-associated GI events in the real world)Tj
/CS0 cs 1 scn
/GS0 gs
0 Tc /Span<>> BDC
-0.503 -1.454 Td
( )Tj
EMC
-0.556 0 Td
(\226)Tj
0 0 0 1 k
/GS1 gs
/C2_0 1 Tf
1.056 0 Td
<0024004A0055004800480050004800510057000300520049000300950003001A0013000800030052005100030057004B0048000300500052005600570003004800490049004800460057004C005900480003005000480057004B0052004700560003>Tj
/TT0 1 Tf
0.003 -1.2 Td
(to manage DMF-associated GI events in a clinical )Tj
T*
(setting)Tj
/CS0 cs 1 scn
/GS0 gs
/Span<>> BDC
-0.503 -1.454 Td
( )Tj
EMC
-0.556 0 Td
(\226)Tj
0 0 0 1 k
/GS1 gs
1.056 0 Td
[(Consensus on managing patients\222)56.4( expectations )]TJ
0.003 -1.2 Td
(around DMF-associated GI events. )Tj
0 0 0 0 k
/GS0 gs
12 0 0 12 121.92 347.2507 Tm
(METHODS)Tj
/CS0 cs 1 scn
8.5 0 0 8.5 36 329.8506 Tm
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
1.059 0 Td
[(A)36.9( steering committee of 6 clinicians with experience )]TJ
T*
(managing patients treated with DMF was convened )Tj
T*
(and the Delphi process selected as the method for )Tj
T*
(obtaining consensus.)Tj
4.9555 0 0 4.9555 132.3699 302.0812 Tm
(4)Tj
/CS0 cs 1 scn
/GS0 gs
-0.005 Tc 0.005 Tw 8.5 0 0 8.5 36 284.5507 Tm
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
0 Tw 1.059 0 Td
[(T)74.4(wo hundred clinicians in the United States and)-4.9( )]TJ
-0.02 Tc T*
[(C)-15.2(a)-15.1(n)-14.9(a)-15.1(d)-14.9(a)-15.1( )-14.9(w)-14.8(i)-14.8(t)-15.1(h)-14.8( )-14.8(the most experience of treating MS patients)-20.2( )]TJ
/C2_0 1 Tf
-0.005 Tc 0.005 Tw T*
[<005A>15.2<004C>15.1<0057>15<004B>15.2<0003>15.1<0027>14.9<0030>14.9<0029>15.2<0003>15.2<000B>15<0045>15.1<0044>14.9<0056>14.8<0048>14.8<0047>15.2<0003>15.2<0052>15.1<0051>15.2<0003>15.1<005300550048005600460055004C00530057004C005200510056001E00030025004C0052004A0048005100030047004400570044000300520051000300BF004F0048000C>-5<0003>]TJ
/TT0 1 Tf
0 Tw T*
(were invited to participate.)Tj
/CS0 cs 1 scn
/GS0 gs
0 Tc -1.059 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
/C2_0 1 Tf
1.059 0 Td
[<0037>74.4<005A00520003005500520058005100470056000300520049000300540058004800560057004C0052005100510044004C005500480056000300460052005100570044004C0051004C0051004A0003004500520057004B0003>]TJ
T*
<00520053004800510010000300440051004700030046004F005200560048001000480051004700480047000300540058004800560057004C0052005100560003005A00480055004800030047004800590048004F005200530048004700110003>Tj
/TT0 1 Tf
T*
(Results from Questionnaire 1 were used to develop )Tj
T*
(Questionnaire 2 and were provided along with )Tj
T*
(Questionnaire 1 in an effort to obtain consensus on )Tj
/C2_0 1 Tf
T*
<0057004B004800030050004400510044004A004800500048005100570003005200490003004800440046004B00030056005300480046004C00BF00460003002A002C0003004800590048005100570011>Tj
/CS0 cs 1 scn
/GS0 gs
/TT0 1 Tf
-0.005 Tc 0.005 Tw -1.059 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
0 Tw 1.059 0 Td
(The structure of Questionnaire 2 is shown in Figure 1.)Tj
/CS0 cs 1 scn
/GS0 gs
0.005 Tc -0.005 Tw -1.059 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
/C2_0 1 Tf
1.059 0 Td
[<0037004B0048000300540058004800560057004C0052005100510044004C0055004800560003005A0048005500480003004400470050004C0051004C005600570048005500480047000300520051004F004C00510048>4.9<0003>]TJ
/TT0 1 Tf
0 Tc 0 Tw 21.948 0 Td
( )Tj
0.005 Tc -21.948 -1.2 Td
[(\(Survey Monkey)74.1(, www)37.3(.surveymonkey)74.1(.com\) and)5.2( )]TJ
/C2_0 1 Tf
-0.005 Tw 0 -1.2 TD
<00550048005600530052005100470048005100570056000300520051004F005C0003004400510056005A0048005500480047000300540058004800560057004C005200510056000300550048004F00480059004400510057>Tj
/TT0 1 Tf
0 Tc 0 Tw 22.554 0 Td
( )Tj
/C2_0 1 Tf
-22.554 -1.2 Td
<00570052000300950003001400030052004900030057004B0048004C00550003005300440057004C00480051005700560011>Tj
/CS0 cs 1 scn
/GS0 gs
/TT0 1 Tf
-0.02 Tc 0.02 Tw -1.059 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
/C2_0 1 Tf
1.059 0 Td
[<0035004800560058004F005700560003004900550052005000030046004F005200560048001000480051004700480047000300540058004800560057004C0052005100560003005A0048005500480003005300550048005600480051005700480047>-19.9<0003>]TJ
/TT0 1 Tf
0 Tw 0 -1.2 TD
[(descriptively \(e.g., percentages\) while open-ended)-19.8( )]TJ
/C2_0 1 Tf
0.02 Tw T*
[<0055004800560053005200510056004800560003005A0048005500480003005700550048004400570048004700030044005600030054>-14.8<0058>-14.9<0044>-15.1<004F>-14.8<004C>-14.9<0057>-15<0044>-15.1<0057>-15.1<004C>-14.8<0059>-15.2<0048>-15.1<0003>-14.8<0047>-14.9<0044>-15.1<0057>-15.1<0044>-15.1<0003>-14.8<0044>-15.2<0051>-14.8<0047>-14.9<000F>-14.8<0003>-14.9<005A>-14.8<004B>-14.8<0048>-15.2<0055>-15.2<0048>-20.1<0003>]TJ
/TT0 1 Tf
-0.005 Tc 0 Tw 0 -1.2 TD
(possible, coded into bins.)Tj
/CS0 cs 1 scn
/GS0 gs
0 Tc -1.059 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
/C2_0 1 Tf
1.059 0 Td
<0037004B0048005600480003004400510044004F005C005600480056000300490052004600580056000300520051000300540058004800560057004C005200510056000300550048004F00440057004C0051004A00030057005200030057004B00480003>Tj
0 -1.2 TD
<0050004400510044004A0048005000480051005700030052004900030056005300480046004C00BF004600030056004C0047004800030048004900490048004600570056000F000300440051004700030048005B005300480055004C0048005100460048>Tj
/TT0 1 Tf
( )Tj
T*
(in typical patients with mild/moderate or severe GI )Tj
24.173 0 Td
( )Tj
-24.173 -1.2 Td
(side effects.)Tj
ET
/CS0 CS 1 SCN
19.875 w 10 M
/GS0 gs
q 1 0 0 1 289.44 428.7106 cm
0 0 m
263.437 0 l
S
Q
BT
0 0 0 0 k
12 0 0 12 393.602 424.6081 Tm
[(RESUL)74.1(TS)]TJ
/CS0 cs 1 scn
8.5 0 0 8.5 289.44 407.2081 Tm
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
1.059 0 Td
(Questionnaire 1 was completed by 64 clinician respondents)Tj
4.9555 0 0 4.9555 539.8184 410.0386 Tm
(5)Tj
8.5 0 0 8.5 542.5745 407.2081 Tm
(; )Tj
-28.722 -1.2 Td
(57 completed Questionnaire 2 and some consensus results )Tj
T*
[(have been presented previously)74.2(.)]TJ
4.9555 0 0 4.9555 429.609 389.6386 Tm
(6)Tj
8.5 0 0 8.5 432.365 386.8081 Tm
( )Tj
/CS0 cs 1 scn
/GS0 gs
-16.815 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
/C2_0 1 Tf
1.059 0 Td
<0024004F004F000300450058005700030014000300550048005600530052005100470048005100570003000B001C001B00080003003E0018001900120018001A0040000C0003004B0044004700030095000300140003005300440057004C004800510057000B0056000C0003005A004B00520003004B004400470003>Tj
/TT0 1 Tf
T*
(experienced a GI side effect with DMF and 96% \(54/56\) had )Tj
28.064 0 Td
( )Tj
/C2_0 1 Tf
-28.064 -1.2 Td
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/CS0 cs 1 scn
/GS0 gs
/TT0 1 Tf
-0.025 Tc 0.025 Tw -1.059 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
0 Tw 1.059 0 Td
[(T)74.4(aking DMF with food was felt to be a useful management)-25( )]TJ
0 -1.2 TD
[(strategy for nausea \(98% [54/55]\), vomiting \(89% [49/55]\), and)-24.9( )]TJ
0 -1.2 TD
(abdominal pain \(93% [51/55]\), but not for diarrhea \(69% [38/55]\).)Tj
/CS0 cs 1 scn
/GS0 gs
0 Tc -1.059 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
1.059 0 Td
(Overall, slower dose titration than that initially recommended )Tj
T*
(\(> 7 days to reach the approved maintenance dose of 240 mg )Tj
T*
(BID\) was thought to be effective for reducing the incidence )Tj
T*
(and/or severity of nausea \(98% [48/49]\), vomiting \(96% [47/49]\), )Tj
T*
(abdominal pain \(94% [46/49]\), and diarrhea \(92% [45/49]\).)Tj
/CS0 cs 1 scn
/GS0 gs
/Span<>> BDC
0.98 -1.454 Td
( )Tj
EMC
-0.556 0 Td
(\226)Tj
0 0 0 1 k
/GS1 gs
1.056 0 Td
[(Details of the physicians\222)55.8( experience of slower titration for )]TJ
0.003 -1.2 Td
(mild/moderate and severe side effects are given in Figure 2.)Tj
/CS0 cs 1 scn
/GS0 gs
-2.541 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
1.059 0 Td
[(T)74.4(emporary dose reduction was considered a useful )]TJ
T*
(management strategy for reducing the impact of nausea \(100% )Tj
T*
([49/49]\), vomiting \(90% [44/49]\), abdominal pain \(90% [44/49]\), )Tj
T*
(and diarrhea \(86% [42/49]\).)Tj
/CS0 cs 1 scn
/GS0 gs
/Span<>> BDC
0.98 -1.454 Td
( )Tj
EMC
-0.556 0 Td
(\226)Tj
0 0 0 1 k
/GS1 gs
/C2_0 1 Tf
1.056 0 Td
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/TT0 1 Tf
0.003 -1.2 Td
(temporary dose reduction.)Tj
/CS0 cs 1 scn
/GS0 gs
-2.541 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
1.059 0 Td
(Consensus was reached on using antacids \(73%\), bismuth )Tj
0 -1.2 TD
(subsalicylate \(71%\), ondansetron \(93%\), or promethazine )Tj
0 -1.2 TD
(\(71%\) for nausea; bismuth subsalicylate \(71%\), ondansetron )Tj
0 -1.2 TD
(\(93%\), or promethazine \(71%\) for vomiting; antacids \(75%\), )Tj
0 -1.2 TD
(bismuth subsalicylate \(77%\), H)Tj
4.9555 0 0 4.9555 423.1427 112.8576 Tm
(2)Tj
8.5 0 0 8.5 425.8987 115.1881 Tm
( blockers \(73%\), or proton )Tj
-14.995 -1.2 Td
(pump inhibitors \(80%\) for abdominal pain; and diphenoxylate/)Tj
T*
(atropine \(91%\) or loperamide \(95%\) for diarrhea.)Tj
/CS0 cs 1 scn
/GS0 gs
/Span<>> BDC
0.955 -1.454 Td
( )Tj
EMC
-0.531 0 Td
(\226)Tj
0 0 0 1 k
/GS1 gs
-0.025 Tc 1.006 0 Td
(Further details on symptomatic therapies are given in Figure 4.)Tj
/CS0 cs 1 scn
/GS0 gs
0 Tc -2.489 -1.729 Td
()Tj
/Span<>> BDC
( )Tj
EMC
0 0 0 1 k
/GS1 gs
1.059 0 Td
(The majority of responders \(98% [55/56]\) agreed that patients )Tj
-0.01 Tc T*
[(should be provided with information on the potential for GI side)-10.1( )]TJ
T*
[(effects \(e.g., occurrence, impact\) as well as on management)-10( )]TJ
T*
[(strategies \(100% [56/56]\) when initiating DMF therapy)74.1(.)]TJ
ET
0 0 0 0 k
/GS0 gs
573.62 517.564 354.68 177.664 re
f
/PlacedPDF /MC0 BDC
/CS0 cs 1 scn
732.284 568.954 11.414 -9.182 re
f
703.653 614.94 11.462 -55.169 re
f
675.07 614.94 11.462 -55.169 re
f
646.487 613.639 11.414 -53.867 re
f
617.904 620.219 11.414 -60.448 re
f
/CS2 cs 1 scn
732.284 582.115 11.414 -13.161 re
f
703.653 630.702 11.462 -15.762 re
f
675.07 630.702 11.462 -15.762 re
f
646.487 629.401 11.414 -15.762 re
f
617.904 630.702 11.414 -10.483 re
f
0 0 0 1 K
0.502 w 1 j
q 1 0 0 1 609.32 559.7714 cm
0 0 m
0 78.812 l
S
Q
q 1 0 0 1 607.2578 638.5834 cm
0 0 m
2.062 0 l
S
Q
q 1 0 0 1 607.2578 612.3381 cm
0 0 m
2.062 0 l
S
Q
q 1 0 0 1 607.2578 586.0165 cm
0 0 m
2.062 0 l
S
Q
q 1 0 0 1 607.2578 559.6104 cm
0 0 m
2.062 0 l
S
Q
q 1 0 0 1 609.32 559.6104 cm
0 0 m
142.963 0 l
S
Q
q 1 0 0 1 752.2828 559.6104 cm
0 0 m
0 -2.194 l
S
Q
q 1 0 0 1 723.6998 559.6104 cm
0 0 m
0 -2.194 l
S
Q
q 1 0 0 1 695.1168 559.6104 cm
0 0 m
0 -2.194 l
S
Q
q 1 0 0 1 666.486 559.6104 cm
0 0 m
0 -2.194 l
S
Q
q 1 0 0 1 637.903 559.6104 cm
0 0 m
0 -2.194 l
S
Q
q 1 0 0 1 609.32 559.6104 cm
0 0 m
0 -2.194 l
S
Q
BT
0 0 0 0 k
/TT1 1 Tf
0 Tc 6.5267 0 0 6.5267 619.9814 586.4427 Tm
(46)Tj
4.379 -0.501 Td
(41)Tj
4.383 0.101 Td
(42)Tj
4.379 0 Td
(42)Tj
4.661 -3.524 Td
(7)Tj
0 0 0 1 k
-17.525 9.362 Td
(8)Tj
4.101 -0.605 Td
(12)Tj
4.383 0.201 Td
(12)Tj
4.379 0 Td
(12)Tj
4.383 -7.247 Td
(10)Tj
-20.409 -2.253 Td
(0)Tj
-0.497 4.018 Td
(20)Tj
0 4.018 TD
(40)Tj
0 4.018 TD
(60)Tj
-0.01 Tc 0.01 Tw 6.0246 0 0 6.0246 613.0458 551.6049 Tm
(Nausea)Tj
-0.025 Tc 0.025 Tw 4.447 0 Td
(Vomiting)Tj
4.317 0 Td
(Abdominal)Tj
1.493 -1.133 Td
(pain)Tj
3.793 1.133 Td
(Diarrhea)Tj
-0.01 Tc 0 Tw 4.859 0 Td
(None of)Tj
-0.023 -1.133 Td
(the side)Tj
-1.139 -1.134 Td
(effects listed)Tj
ET
/CS2 cs 1 scn
648.216 647.52 3.854 3.854 re
f*
q
582.944 535.753 341.275 117.14 re
W n
BT
0 0 0 1 k
/TT2 1 Tf
0 Tc 6.0246 0 0 6.0246 654.1113 647.496 Tm
(Slower titration generally NOT effective)Tj
ET
Q
/CS0 cs 1 scn
773.426 647.52 3.854 3.854 re
f*
q
582.944 535.753 341.275 117.14 re
W n
BT
0 0 0 1 k
/TT2 1 Tf
0 Tc 6.0246 0 0 6.0246 779.3215 647.496 Tm
(Slower titration generally effective)Tj
ET
Q
BT
0 0 0 1 k
0 Tc 6.5267 0 0 6.5267 636.9267 636.8529 Tm
(Mild/moderate cases \(n=55)Tj
3.8051 0 0 3.8051 720.1772 639.0264 Tm
(b)Tj
6.5267 0 0 6.5267 722.5012 636.8529 Tm
(\))Tj
ET
/CS0 cs 1 scn
868.485 595.274 11.462 -35.503 re
f
839.902 601.855 11.414 -42.084 re
f
811.319 604.457 11.414 -44.686 re
f
782.688 608.435 11.462 -48.664 re
f
/CS2 cs 1 scn
897.068 567.652 11.462 14.461 re
f
/CS0 cs 1 scn
897.068 559.771 11.462 7.881 re
f
/CS2 cs 1 scn
868.485 626.799 11.462 -31.525 re
f
839.902 628.101 11.414 -26.245 re
f
811.319 626.799 11.414 -22.342 re
f
782.688 628.101 11.462 -19.664 re
f
q 1 0 0 1 774.1516 559.771 cm
0 0 m
0 78.889 l
S
Q
q 1 0 0 1 772.0895 638.6594 cm
0 0 m
2.062 0 l
S
Q
q 1 0 0 1 772.0895 612.3378 cm
0 0 m
2.062 0 l
S
Q
q 1 0 0 1 772.0895 586.0927 cm
0 0 m
2.062 0 l
S
Q
q 1 0 0 1 772.0895 559.61 cm
0 0 m
2.062 0 l
S
Q
q 1 0 0 1 774.1516 559.61 cm
0 0 m
142.963 0 l
S
Q
q 1 0 0 1 917.1145 559.61 cm
0 0 m
0 -2.194 l
S
Q
q 1 0 0 1 888.5315 559.61 cm
0 0 m
0 -2.194 l
S
Q
q 1 0 0 1 859.9005 559.61 cm
0 0 m
0 -2.194 l
S
Q
q 1 0 0 1 831.3176 559.61 cm
0 0 m
0 -2.194 l
S
Q
q 1 0 0 1 802.7346 559.61 cm
0 0 m
0 -2.194 l
S
Q
q 1 0 0 1 774.1516 559.61 cm
0 0 m
0 -2.194 l
S
Q
BT
0 0 0 0 k
6.5267 0 0 6.5267 784.7891 580.5494 Tm
(37)Tj
4.383 -0.302 Td
(34)Tj
4.379 -0.202 Td
(32)Tj
4.383 -0.504 Td
(27)Tj
0 0 0 1 k
4.379 -0.255 Td
(11)Tj
-17.525 6.499 Td
(15)Tj
4.383 -0.402 Td
(17)Tj
4.379 -0.102 Td
(20)Tj
4.383 -0.605 Td
(24)Tj
0 0 0 0 k
4.657 -7.036 Td
(6)Tj
0 0 0 1 k
-20.687 -0.651 Td
(0)Tj
-0.497 4.017 Td
(20)Tj
0 4.017 TD
(40)Tj
0 4.017 TD
(60)Tj
-0.01 Tc 0.01 Tw 6.0246 0 0 6.0246 777.8536 551.4225 Tm
(Nausea)Tj
-0.025 Tc 0.025 Tw 4.451 0 Td
(Vomiting)Tj
4.313 0 Td
(Abdominal)Tj
1.493 -1.133 Td
(pain)Tj
3.797 1.133 Td
(Diarrhea)Tj
-0.01 Tc 0 Tw 4.855 0 Td
(None of)Tj
-0.023 -1.133 Td
(the side)Tj
-1.139 -1.134 Td
(effects listed)Tj
0 Tc 6.5267 0 0 6.5267 813.1747 636.8529 Tm
(Severe cases \(n=53)Tj
3.8051 0 0 3.8051 873.5946 639.0264 Tm
(b)Tj
6.5267 0 0 6.5267 875.9186 636.8529 Tm
(\))Tj
ET
q
582.944 535.753 341.275 117.14 re
W n
BT
0 6.5267 -6.5267 0 590.0004 569.4445 Tm
(No. of respondents)Tj
ET
EMC
Q
/CS0 CS 1 SCN
1 w 4 M 0 j
573.62 517.564 354.68 177.664 re
S
/CS0 cs 1 scn
573.12 676.026 355.68 19.843 re
f
BT
0 0 0 0 k
/TT0 1 Tf
8.5 0 0 8.5 578.7893 682.8531 Tm
(Figure 2. )Tj
/TT3 1 Tf
4.445 0 Td
(Experience using slower titration)Tj
ET
573.62 344.044 354.68 164.818 re
f
/PlacedPDF /MC1 BDC
q
580.85 354.391 341.194 122.792 re
W n
/CS0 cs 1 scn
q 1 0 0 1 638.6288 462.3219 cm
0 0 m
8.231 0 16.335 -1.999 23.62 -5.823 c
0 -50.828 l
h
f*
Q
/CS2 cs 1 scn
q 1 0 0 1 662.2488 456.4995 cm
0 0 m
5.456 -2.859 10.344 -6.688 14.425 -11.298 c
-23.62 -45.006 l
h
f*
Q
/CS3 cs 1 scn
q 1 0 0 1 676.6738 445.2008 cm
0 0 m
15.51 -17.504 17.069 -43.333 3.787 -62.578 c
-38.045 -33.707 l
h
f*
Q
/CS4 cs 1 scn
q 1 0 0 1 680.4609 382.6231 cm
0 0 m
-15.947 -23.106 -47.602 -28.908 -70.708 -12.961 c
-93.809 2.984 -99.61 34.641 -83.664 57.747 c
-74.176 71.495 -58.539 79.699 -41.832 79.699 c
-41.832 28.87 l
h
f*
Q
Q
BT
/TT4 1 Tf
6.5186 0 0 6.5186 646.5538 450.5467 Tm
(4)Tj
0 0 0 1 k
2.37 -1.309 Td
(3)Tj
2.234 -4.828 Td
(11)Tj
-11.89 -3.683 Td
(34)Tj
ET
/CS0 cs 1 scn
700.35 439.662 3.73 3.73 re
f*
BT
0 0 0 1 k
/TT5 1 Tf
6.0172 0 0 6.0172 705.8041 439.5558 Tm
(I)Tj
0.275 0 Td
( )Tj
0.281 0 Td
(a)Tj
(l)Tj
0.771 0 Td
(way)Tj
(s)Tj
2.274 0 Td
( )Tj
0.281 0 Td
(u)Tj
0.552 0 Td
(s)Tj
0.494 0 Td
(e a se)Tj
(t)Tj
3 0 Td
( )Tj
0.274 0 Td
(le)Tj
(n)Tj
1.329 0 Td
(gth o)Tj
(f)Tj
2.498 0 Td
( )Tj
0.281 0 Td
(t)Tj
(i)Tj
0.492 0 Td
(m)Tj
0.836 0 Td
(e)Tj
ET
/CS2 cs 1 scn
700.35 427.142 3.73 3.73 re
f*
BT
0 0 0 1 k
6.0172 0 0 6.0172 705.8041 427.0356 Tm
(T)Tj
(h)Tj
1.164 0 Td
(e )Tj
(l)Tj
1.052 0 Td
(engt)Tj
-0.004 Tc 0.004 Tw (h )Tj
0 Tc 0 Tw 2.772 0 Td
(of ti)Tj
(m)Tj
2.443 0 Td
(e)Tj
( )Tj
0.828 0 Td
(d)Tj
0.559 0 Td
(e)Tj
(p)Tj
1.106 0 Td
(e)Tj
(n)Tj
1.106 0 Td
(d)Tj
0.559 0 Td
(s)Tj
0.494 0 Td
( )Tj
0.281 0 Td
(o)Tj
0.55 0 Td
(n)Tj
0.552 0 Td
( )Tj
0.281 0 Td
(t)Tj
(h)Tj
0.829 0 Td
(e)Tj
-14.577 -1.214 Td
(s)Tj
(i)Tj
0.717 0 Td
(d)Tj
0.559 0 Td
(e)Tj
( )Tj
0.828 0 Td
(ef)Tj
(f)Tj
1.107 0 Td
(ect)Tj
( )Tj
1.609 0 Td
(\()Tj
0.336 0 Td
(e)Tj
(.)Tj
0.828 0 Td
(g)Tj
(.)Tj
0.829 0 Td
(,)Tj
-0.004 Tw 0.283 0 Td
( n)Tj
0 Tw 0.826 0 Td
(a)Tj
(u)Tj
1.108 0 Td
(sea,)Tj
( )Tj
2.162 0 Td
(v)Tj
(o)Tj
1.058 0 Td
(m)Tj
0.83 0 Td
(iti)Tj
(n)Tj
1.274 0 Td
(g,)Tj
-14.354 -1.213 Td
(a)Tj
-0.004 Tc 0.004 Tw (bd)Tj
0 Tc 0 Tw (omi)Tj
(n)Tj
3.824 0 Td
(al)Tj
( )Tj
1.053 0 Td
(p)Tj
0.559 0 Td
(a)Tj
(i)Tj
0.771 0 Td
(n)Tj
0.559 0 Td
(,)Tj
( )Tj
0.55 0 Td
(d)Tj
0.552 0 Td
(iar)Tj
(r)Tj
1.44 0 Td
(h)Tj
0.559 0 Td
(ea\))Tj
ET
/CS3 cs 1 scn
700.35 399.58 3.73 3.73 re
f*
BT
0 0 0 1 k
6.0172 0 0 6.0172 705.8041 399.4628 Tm
(T)Tj
(h)Tj
1.164 0 Td
(e )Tj
(l)Tj
1.052 0 Td
(engt)Tj
-0.004 Tc 0.004 Tw (h )Tj
0 Tc 0 Tw 2.772 0 Td
(of ti)Tj
(m)Tj
2.443 0 Td
(e)Tj
( )Tj
0.828 0 Td
(d)Tj
0.559 0 Td
(e)Tj
(p)Tj
1.106 0 Td
(e)Tj
(n)Tj
1.106 0 Td
(d)Tj
0.559 0 Td
(s)Tj
0.494 0 Td
( )Tj
0.281 0 Td
(o)Tj
0.55 0 Td
(n)Tj
0.552 0 Td
( )Tj
0.281 0 Td
(t)Tj
(h)Tj
0.829 0 Td
(e)Tj
-14.577 -1.213 Td
(se)Tj
(v)Tj
1.549 0 Td
(erity)Tj
( )Tj
2.161 0 Td
(of t)Tj
(h)Tj
1.943 0 Td
(e)Tj
( )Tj
0.828 0 Td
(side e)Tj
(f)Tj
2.94 0 Td
(fe)Tj
(c)Tj
1.331 0 Td
(ts)Tj
( )Tj
1.053 0 Td
(\()Tj
0.336 0 Td
(i)Tj
0.215 0 Td
(.)Tj
0.28 0 Td
(e)Tj
(.)Tj
0.828 0 Td
(, how)Tj
-13.464 -1.212 Td
(l)Tj
(o)Tj
0.773 0 Td
(n)Tj
0.559 0 Td
(g)Tj
( )Tj
0.829 0 Td
(it)Tj
( )Tj
0.773 0 Td
(ta)Tj
(k)Tj
1.331 0 Td
(es)Tj
( )Tj
1.33 0 Td
(to d)Tj
(i)Tj
1.886 0 Td
(s)Tj
(s)Tj
1.002 0 Td
(i)Tj
0.215 0 Td
(p)Tj
0.559 0 Td
(at)Tj
(e)Tj
1.387 0 Td
(/)Tj
(r)Tj
0.603 0 Td
(eso)Tj
(l)Tj
1.83 0 Td
(ve\))Tj
ET
/CS4 cs 1 scn
700.35 372.016 3.73 3.73 re
f*
BT
0 0 0 1 k
6.0172 0 0 6.0172 705.8041 371.8996 Tm
(De)Tj
(p)Tj
1.828 0 Td
(e)Tj
(n)Tj
1.106 0 Td
(d)Tj
0.559 0 Td
(s)Tj
0.494 0 Td
( )Tj
0.281 0 Td
(o)Tj
0.55 0 Td
(n)Tj
0.559 0 Td
( )Tj
0.274 0 Td
(s)Tj
(i)Tj
0.717 0 Td
(d)Tj
0.559 0 Td
(e)Tj
( )Tj
0.828 0 Td
(ef)Tj
(f)Tj
1.107 0 Td
(ect)Tj
( )Tj
1.609 0 Td
(a)Tj
(n)Tj
1.108 0 Td
(d)Tj
0.559 0 Td
( )Tj
0.274 0 Td
(se)Tj
(v)Tj
1.549 0 Td
(erity)Tj
/TT4 1 Tf
6.5186 0 0 6.5186 594.8455 470.1363 Tm
(M)Tj
(i)Tj
1.114 0 Td
(l)Tj
0.28 0 Td
(d/mod)Tj
(e)Tj
3.557 0 Td
(rate)Tj
( )Tj
2.118 0 Td
(c)Tj
0.559 0 Td
(a)Tj
(s)Tj
1.115 0 Td
(e)Tj
(s)Tj
1.114 0 Td
( \(n=55)Tj
3.8004 0 0 3.8004 678.1235 472.307 Tm
(a)Tj
6.5186 0 0 6.5186 680.2369 470.1363 Tm
(\))Tj
23.694 0 Td
(Se)Tj
(v)Tj
1.784 0 Td
(ere ca)Tj
(s)Tj
3.453 0 Td
(e)Tj
(s)Tj
1.115 0 Td
( \(n=53)Tj
3.8004 0 0 3.8004 895.1202 472.307 Tm
(a)Tj
6.5186 0 0 6.5186 897.2336 470.1363 Tm
(\))Tj
ET
q
580.85 354.391 341.194 122.792 re
W n
/CS0 cs 1 scn
q 1 0 0 1 867.0505 462.2747 cm
0 0 m
10.79 0 21.302 -3.415 30.03 -9.757 c
0 -51.085 l
h
f*
Q
/CS2 cs 1 scn
q 1 0 0 1 897.0807 452.5182 cm
0 0 m
3.467 -2.518 6.599 -5.466 9.332 -8.765 c
-30.03 -41.329 l
h
f*
Q
/CS3 cs 1 scn
q 1 0 0 1 906.4122 443.7531 cm
0 0 m
15.632 -18.899 15.632 -46.233 0 -65.132 c
-39.361 -32.564 l
h
f*
Q
/CS4 cs 1 scn
q 1 0 0 1 906.4122 378.6207 cm
0 0 m
-17.981 -21.737 -50.188 -24.785 -71.925 -6.798 c
-93.668 11.189 -96.71 43.39 -78.729 65.132 c
-69.019 76.862 -54.589 83.654 -39.361 83.654 c
-39.361 32.569 l
h
f*
Q
Q
BT
0 0 0 0 k
6.5186 0 0 6.5186 874.6251 446.4818 Tm
(5)Tj
0 0 0 1 k
3.023 -1.011 Td
(2)Tj
1.687 -4.923 Td
(11)Tj
-12.131 -3.079 Td
(32)Tj
ET
EMC
573.62 344.044 354.68 164.818 re
S
/CS0 cs 1 scn
573.12 489.52 355.68 19.843 re
f
BT
0 0 0 0 k
/TT0 1 Tf
8.5 0 0 8.5 578.7893 496.3475 Tm
(Figure 3. )Tj
/C2_1 1 Tf
4.445 0 Td
<00290044004600570052005500560003004C005100C00058004800510046004C0051004A00030057004B0048000300470058005500440057004C00520051000300520049000300570048005000530052005500440055005C000300470052005600480003005500480047005800460057004C00520051>Tj
ET
573.62 36.5 354.68 298.52 re
f
/PlacedPDF /MC2 BDC
/CS0 cs 1 scn
852.915 271.16 6.37 -14.431 re
f
824.29 268.847 6.37 -12.117 re
f
795.693 278.676 6.342 -21.947 re
f
767.067 282.145 6.37 -25.415 re
f
738.442 269.425 6.37 -12.696 re
f
709.844 275.785 6.342 -19.056 re
f
681.218 261.909 6.37 -5.18 re
f
652.593 279.254 6.37 -22.525 re
f
623.996 276.364 6.342 -19.634 re
f
/CS2 cs 1 scn
859.286 259.596 6.342 -2.867 re
f
830.66 259.596 6.342 -2.867 re
f
802.035 256.729 6.37 0.553 re
f
744.812 259.018 6.37 -2.288 re
f
716.187 261.909 6.37 -5.18 re
f
687.589 259.596 6.342 -2.867 re
f
658.963 259.596 6.37 -2.867 re
f
630.338 262.487 6.37 -5.758 re
f
/CS3 cs 1 scn
865.628 271.738 6.37 -15.009 re
f
837.003 274.051 6.37 -17.321 re
f
808.405 261.909 6.342 -5.18 re
f
779.78 263.643 6.37 -6.914 re
f
751.182 274.051 6.342 -17.321 re
f
722.557 264.8 6.342 -8.07 re
f
693.932 280.989 6.37 -24.259 re
f
665.333 263.643 6.342 -6.914 re
f
636.708 263.643 6.342 -6.914 re
f
BT
0 0 0 1 k
/TT6 1 Tf
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(34)Tj
4.793 0.484 Td
(39)Tj
5.084 -2.904 Td
(9)Tj
4.497 2.324 Td
(33)Tj
4.793 -1.065 Td
(22)Tj
4.789 2.126 Td
(44)Tj
4.793 -0.577 Td
(38)Tj
4.793 -1.646 Td
(21)Tj
4.788 0.387 Td
(25)Tj
-37.265 -1.452 Td
(10)Tj
5.108 -0.484 Td
(5)Tj
4.791 0 Td
(5)Tj
28.75 0 Td
(5)Tj
-23.979 0.387 Td
(9)Tj
4.789 -0.484 Td
(4)Tj
4.793 -0.387 Td
(0)Tj
4.793 0.097 Td
(1)Tj
4.788 0.387 Td
(5)Tj
-32.732 0.678 Td
(12)Tj
4.793 0 Td
(12)Tj
4.754 2.9 Td
(42)Tj
4.788 -2.707 Td
(14)Tj
4.793 1.549 Td
(30)Tj
4.788 -1.743 Td
(12)Tj
5.089 -0.291 Td
(9)Tj
4.497 2.033 Td
(30)Tj
4.789 -0.387 Td
(26)Tj
-42.402 -3.473 Td
(0)Tj
-0.556 1.936 Td
(20)Tj
0 1.932 TD
(40)Tj
0 1.936 TD
(60)Tj
0.556 -18.979 Td
(0)Tj
-0.556 1.936 Td
(20)Tj
0 1.932 TD
(40)Tj
0 1.936 TD
(60)Tj
0.556 -16.424 Td
(0)Tj
-0.556 1.936 Td
(20)Tj
0 1.932 TD
(40)Tj
0 1.936 TD
(60)Tj
0.556 -16.424 Td
(0)Tj
-0.556 1.936 Td
(20)Tj
0 1.932 TD
(40)Tj
0 1.936 TD
(60)Tj
ET
q
583.815 42.122 338.29 260.493 re
W n
BT
6.4698 0 0 6.4698 586.0313 297.1482 Tm
(Nausea)Tj
ET
Q
BT
6.4698 0 0 6.4698 586.0313 218.4679 Tm
(V)Tj
0.615 0 Td
(omiti)Tj
(n)Tj
2.998 0 Td
(g)Tj
ET
/CS0 cs 1 scn
840.805 194.417 9.567 -16.166 re
f
797.807 191.527 9.567 -13.276 re
f
754.809 204.803 9.567 -26.552 re
f
711.809 191.527 9.567 -13.276 re
f
668.811 181.142 9.567 -2.891 re
f
625.812 190.966 9.567 -12.714 re
f
/CS2 cs 1 scn
850.372 178.252 9.54 0.562 re
f
807.374 180.553 9.54 -2.302 re
f
764.375 178.252 9.541 0.562 re
f
721.377 179.403 9.54 -1.151 re
f
678.378 180.553 9.54 -2.302 re
f
635.379 182.293 9.54 -4.042 re
f
/CS3 cs 1 scn
859.913 193.829 9.567 -15.577 re
f
816.914 195.007 9.567 -16.756 re
f
773.915 183.444 9.567 -5.193 re
f
730.917 196.157 9.567 -17.906 re
f
687.919 205.392 9.567 -27.14 re
f
644.92 193.829 9.567 -15.577 re
f
BT
0 0 0 1 k
5.9721 0 0 5.9721 627.2062 195.326 Tm
(22)Tj
7.486 -1.64 Td
(5)Tj
6.914 1.739 Td
(23)Tj
7.196 2.223 Td
(46)Tj
7.201 -2.223 Td
(23)Tj
7.2 0.484 Td
(28)Tj
-34.112 -2.03 Td
(7)Tj
7.2 -0.291 Td
(4)Tj
7.2 -0.193 Td
(2)Tj
7.2 -0.099 Td
(1)Tj
7.2 0.291 Td
(4)Tj
7.2 -0.291 Td
(1)Tj
-34.683 2.514 Td
(27)Tj
7.2 1.923 Td
(47)Tj
7.2 -1.533 Td
(31)Tj
7.486 -2.129 Td
(9)Tj
6.914 1.932 Td
(29)Tj
7.2 -0.193 Td
(27)Tj
-0.025 Tc 0.025 Tw 5.4744 0 0 5.4744 629.611 170.8543 Tm
(Bismuth)Tj
/C2_2 1 Tf
-1.066 -1.2 Td
<00560058004500560044004F004C0046005C004F004400570048>Tj
/TT6 1 Tf
0.447 -10.359 Td
(Antacids)Tj
0 Tc 0 Tw 4.5943 2.9769 -2.9769 4.5943 617.6224 237.3646 Tm
[(A)25(n)25(t)25(a)25(c)25(i)25(d)25(s)]TJ
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(Bismuth)Tj
/C2_2 1 Tf
-1.066 -1.2 Td
<00560058004500560044004F004C0046005C004F004400570048>Tj
6.901 1.2 Td
<0027004C0046005C0046004F00520050004C00510048>Tj
/TT6 1 Tf
0 Tc 0 Tw 6.952 0 Td
(H)Tj
3.1916 0 0 3.1916 737.4345 106.2528 Tm
(2)Tj
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( blockers)Tj
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(H)Tj
2.6785 1.7355 -1.7355 2.6785 702.1116 234.9048 Tm
(2)Tj
4.5943 2.9769 -2.9769 4.5943 702.8138 236.9386 Tm
[( )25(b)25(l)25(o)25(c)25(k)25(e)25(r)25(s)]TJ
-0.025 Tc 5.4744 0 0 5.4744 768.3477 107.5777 Tm
(Proton pump)Tj
0.025 Tw 0.82 -1.2 Td
(inhibitors)Tj
0 Tc 0 Tw 4.5943 2.9769 -2.9769 4.5943 773.5132 232.0995 Tm
[(P)25(r)25(o)25(t)25(o)25(n)25( )25(p)25(u)25(m)25(p)25( )25( )25( )25( )25( )25( )]TJ
3.158 -1.091 Td
[(i)25(n)25(h)25(i)25(b)25(i)25(t)25(o)25(r)25(s)]TJ
-0.025 Tc 0.025 Tw 5.4744 0 0 5.4744 805.9484 107.5777 Tm
(Simethicone)Tj
7.273 0 Td
(Sucralfate)Tj
/C2_2 1 Tf
-33.321 11.559 Td
<0027004C005000480051004B005C00470055004C005100440057>Tj
/TT6 1 Tf
0 Tc 0 Tw (e)Tj
/C2_2 1 Tf
4.5943 2.9769 -2.9769 4.5943 660.2156 227.8859 Tm
[<0027>25<004C>25<0050>25<0048>25<0051>25<004B>25<005C>25<0047>25<0055>24.9<004C>25<0051>25<0044>25<0057>]TJ
/TT6 1 Tf
6.676 -0 Td
(e)Tj
-0.025 Tc 0.025 Tw 5.4744 0 0 5.4744 706.0469 170.8543 Tm
(Metoclopramid)Tj
0 Tc 0 Tw (e)Tj
4.5943 2.9769 -2.9769 4.5943 716.9581 227.5558 Tm
[(M)25(e)25(t)25(o)25(c)25(l)25(o)25(p)25(r)25(a)25(m)25(i)25(d)]TJ
6.787 0 Td
(e)Tj
-0.025 Tc 0.025 Tw 5.4744 0 0 5.4744 752.7963 170.8543 Tm
(Ondansetro)Tj
0 Tc 0 Tw (n)Tj
4.5943 2.9769 -2.9769 4.5943 751.8666 231.6354 Tm
[(O)25(n)25(d)25(a)25(n)25(s)25(e)25(t)25(r)25(o)]TJ
5.362 0 Td
(n)Tj
-0.025 Tc 0.025 Tw 5.4744 0 0 5.4744 790.8102 170.8543 Tm
(Prochlorperazin)Tj
0 Tc 0 Tw (e)Tj
4.5943 2.9769 -2.9769 4.5943 800.7068 226.2126 Tm
[(P)25(r)25(o)25(c)25(h)25(l)25(o)25(r)25(p)25(e)25(r)25(a)25(z)25(i)25(n)]TJ
7.238 0 Td
(e)Tj
/C2_2 1 Tf
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<0025004C0056005000580057004B000300560058004500560044004F004C0046005C004F004400570048>Tj
/TT6 1 Tf
0 Tc 0 Tw 4.5943 2.9769 -2.9769 4.5943 640.1882 238.4137 Tm
[(B)25(i)25(s)25(m)25(u)25(t)25(h)25( )25( )25( )25( )25( )25( )]TJ
/C2_2 1 Tf
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[<0056>25<0058>25<0045>25<0056>25<0044>25<004F>25<004C>25<0046>25<005C>25<004F>25<0044>25<0057>25<0048>]TJ
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<0027004C0053004B004800510052005B005C004F004400570048001200440057005500520053004C00510048>Tj
/TT6 1 Tf
18.25 0 Td
(Loperamide)Tj
3.498 23.136 Td
(Promethazin)Tj
0 Tc 0 Tw (e)Tj
4.5943 2.9769 -2.9769 4.5943 836.2773 230.7134 Tm
[(P)25(r)25(o)25(m)25(e)25(t)25(h)25(a)25(z)25(i)25(n)]TJ
5.726 -0 Td
(e)Tj
6.4698 0 0 6.4698 586.0313 155.0464 Tm
(Abdo)Tj
(m)Tj
3.44 0 Td
(inal)Tj
( )Tj
1.991 0 Td
(pain)Tj
ET
/CS0 cs 1 scn
846.039 120.646 8.177 -5.777 re
f
809.183 122.961 8.201 -8.093 re
f
772.351 135.662 8.177 -20.793 re
f
735.495 134.491 8.177 -19.623 re
f
698.638 122.961 8.202 -8.093 re
f
661.806 137.381 8.177 -22.512 re
f
624.949 136.808 8.202 -21.939 re
f
/CS2 cs 1 scn
854.216 117.758 8.202 -2.889 re
f
817.384 116.039 8.177 -1.17 re
f
780.527 121.218 8.177 -6.35 re
f
743.672 122.389 8.201 -7.52 re
f
706.838 114.868 8.177 0.573 re
f
669.983 119.499 8.202 -4.631 re
f
633.15 120.646 8.177 -5.777 re
f
/CS3 cs 1 scn
862.418 137.953 8.177 -23.085 re
f
825.561 137.953 8.177 -23.085 re
f
788.704 120.073 8.201 -5.205 re
f
751.872 120.073 8.177 -5.205 re
f
715.015 138.55 8.202 -23.681 re
f
678.183 120.073 8.177 -5.205 re
f
641.327 119.499 8.202 -4.631 re
f
BT
0 0 0 1 k
5.9721 0 0 5.9721 625.9018 140.7207 Tm
(38)Tj
6.167 0.096 Td
(39)Tj
6.171 -2.414 Td
(14)Tj
6.172 1.931 Td
(34)Tj
6.167 0.196 Td
(36)Tj
6.171 -2.127 Td
(14)Tj
6.167 -0.388 Td
(10)Tj
-35.647 0 Td
(10)Tj
6.437 -0.192 Td
(8)Tj
6.167 -0.68 Td
(1)Tj
5.905 1.159 Td
(13)Tj
6.172 -0.192 Td
(11)Tj
6.433 -0.868 Td
(2)Tj
6.171 0.288 Td
(5)Tj
-35.647 0.292 Td
(8)Tj
6.167 0.096 Td
(9)Tj
5.906 3.094 Td
(41)Tj
6.433 -3.094 Td
(9)Tj
5.97 0 Td
(9)Tj
6.103 2.994 Td
(4)Tj
(0)Tj
6.021 0 Td
(40)Tj
-0.001 Tc 0.001 Tw 6.4698 0 0 6.4698 586.0313 91.6258 Tm
(Diarrhe)Tj
0 Tc 0 Tw (a)Tj
ET
/CS0 cs 1 scn
804.981 79.268 19.088 -27.648 re
f
719.005 71.781 19.088 -20.161 re
f
633.028 71.194 19.088 -19.575 re
f
/CS2 cs 1 scn
824.07 51.62 19.114 0.588 re
f
738.094 52.77 19.115 -1.15 re
f
652.117 56.807 19.115 -5.187 re
f
/CS3 cs 1 scn
843.184 55.657 19.115 -4.037 re
f
757.208 62.557 19.115 -10.937 re
f
671.232 59.108 19.115 -7.487 re
f
BT
0 0 0 1 k
5.9721 0 0 5.9721 639.1835 75.0422 Tm
(34)Tj
14.396 0.098 Td
(35)Tj
14.396 1.254 Td
(48)Tj
-25.31 -3.761 Td
(9)Tj
14.396 -0.676 Td
(2)Tj
14.396 -0.098 Td
(1)Tj
-25.878 1.159 Td
(13)Tj
14.401 0.578 Td
(19)Tj
14.678 -1.155 Td
(7)Tj
0 5.9721 -5.9721 0 597.0764 59.7183 Tm
(No.)Tj
( )Tj
1.885 0 Td
(of )Tj
-3.325 -1.029 Td
(r)Tj
0.39 0 Td
(e)Tj
(s)Tj
-0.002 Tc 0.002 Tw 1.111 0 Td
(ponden)Tj
0 Tc 0 Tw (t)Tj
3.93 0 Td
(s)Tj
6.629 1.029 Td
(No.)Tj
( )Tj
1.885 0 Td
(of )Tj
-3.326 -1.029 Td
(r)Tj
0.39 0 Td
(e)Tj
(s)Tj
-0.002 Tc 0.002 Tw 1.111 0 Td
(ponden)Tj
0 Tc 0 Tw (t)Tj
3.93 0 Td
(s)Tj
6.682 1.029 Td
(No.)Tj
( )Tj
1.885 0 Td
(of )Tj
-3.326 -1.029 Td
(r)Tj
0.39 0 Td
(e)Tj
(s)Tj
-0.002 Tc 0.002 Tw 1.111 0 Td
(ponden)Tj
0 Tc 0 Tw (t)Tj
3.93 0 Td
(s)Tj
9.086 1.029 Td
(No.)Tj
( )Tj
1.885 0 Td
(of )Tj
-3.325 -1.029 Td
(r)Tj
0.39 0 Td
(e)Tj
(s)Tj
-0.002 Tc 0.002 Tw 1.111 0 Td
(ponden)Tj
0 Tc 0 Tw (t)Tj
3.93 0 Td
(s)Tj
ET
/CS0 cs 1 scn
882.735 293.495 3.583 -3.583 re
f
/CS2 cs 1 scn
882.735 285.739 3.583 -3.583 re
f
/CS3 cs 1 scn
882.735 277.395 3.583 -3.583 re
f
BT
0 0 0 1 k
/TT7 1 Tf
5.9721 0 0 5.9721 890.6232 289.7696 Tm
(Y)Tj
0.596 0 Td
(es)Tj
-0.596 -1.299 Td
(N)Tj
0.724 0 Td
(o)Tj
-0.724 -1.397 Td
(Didn)Tj
2.057 0 Td
(\222)Tj
0.223 0 Td
(t try)Tj
ET
0 0 0 1 K
0.498 w 10 M 1 j
q 1 0 0 1 618.8601 257.0168 cm
0 0 m
0 34.476 l
S
Q
q 1 0 0 1 616.8159 291.4922 cm
0 0 m
2.044 0 l
S
Q
q 1 0 0 1 616.8159 268.4021 cm
0 0 m
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S
Q
q 1 0 0 1 616.8159 279.9471 cm
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S
Q
q 1 0 0 1 616.8159 256.8571 cm
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2.044 0 l
S
Q
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257.772 0 l
S
Q
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S
Q
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Q
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Q
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Q
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Q
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Q
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Q
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Q
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S
Q
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Q
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Q
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Q
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S
Q
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S
Q
q 1 0 0 1 618.8601 178.4394 cm
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S
Q
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Q
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Q
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Q
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Q
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Q
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Q
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Q
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Q
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Q
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/CS0 cs 1 scn
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[(Phillips JT)111.9(, )]TJ
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(. )Tj
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T*
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(Specific questions about the use )Tj
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BT
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BT
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(Specific questions on the )Tj
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BT
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(Questions about management )Tj
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(strategies for GI side effects, )Tj
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(including taking medication with )Tj
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