Multiple Sclerosis & Sleep Disorders: Exploration of Sleep Latency and REM Sleep Latency in a Community Cohort of Patients with Multiple Sclerosis Who Report Fatigue
Objectives: To identify polysomnography documented first night sleep abnormalities related to sleep latency and REM latency in a large cohort of patients with Multiple Sclerosis (MS) who report fatigue.
Methods: Retrospective analysis of patients with MS who reported fatigue, and underwent overnight PSG studies.
Results: 206 patients with MS who reported fatigue completed overnight PSG. Analysis of SL in these patients identified <30 Minutes in 102/207 (49%), SL >30 Minutes 105/207 (51%), and >60 Minutes 52/207(25%). No REM sleep was identified in 25/206 (12%) of these patients. In those patients who reached REM sleep: 115/181 (63%) had REM-L>110 minutes, 63/181 (35%) had REM-L>180 minutes. Of those patient who achieved REM sleep, Normal % REM sleep range was identified in 67/180 (37%); 105/180 (58%) had <17% total REM sleep; and 50/180 (28%) had <10% REM.
Conclusions: Fatigue is a common in patients with MS. Sleep disorders are common in patients with MS with fatigue. Prolonged sleep latency and REM latency are common in patients with MS. Prolonged latency to sleep onset and REM sleep onset can result in less time available for sleep and for REM sleep and might directly contribute to daytime fatigue in patients with MS by directly reducing the available time to sleep per night.