Comprehensive Profile of Cardiopulmonary Exercise Testing in Ambulatory Persons with Multiple Sclerosis
Objectives: The objective of this study was to provide a comprehensive examination of outcome variables from CPET among persons with MS and healthy controls.
Methods: We enrolled 162 persons with MS and 80 healthy controls who underwent a CPET on a leg ergometer for measuring oxygen uptake (VO2), carbon dioxide production (VCO2), ventilation (VE), respiratory exchange ratio, work rate, and heart rate (HR). Calculated variables (i.e., ventilatory anaerobic threshold (VO2/VCO2), VE/VCO2 slope, VO2/Power slope, VO2/HR slope, and Oxygen Uptake Efficiency Slope) were processed using standard guidelines. We examined differences in the CPET variables between groups (e.g., MS vs. controls & categories of mild, moderate, and severe disability status) using ANCOVA, controlling for age, sex, body mass index, and disease duration.
Results: Overall, persons with MS demonstrate alterations in outcomes from CPET compared to controls and these are generally exacerbated with increasing disability.
Conclusions: Our results provide novel information for the evaluation of CPET in MS for developing exercise prescriptions and documenting adaptations with exercise training based on the comprehensive variables obtained during a CPET.