Mind-MS: Exploring the Effects of a Mindfulness-Based Intervention on Cognitive Function, Magnetic Resonance Imaging and Patient Reported Outcomes in MS Patients

Background: In multiple sclerosis (MS), hidden symptoms such as cognitive impairment, fatigue and depression are difficult to treat and pose a major impact on quality of life and work force participation. Mindfulness based interventions (MBIs) have been shown to improve fatigue and depressive symptoms in MS and hold the potential to have a positive impact on cognitive function and induce structural changes in the brain in regions important for memory and attention.  

Objectives: To explore effects of a MBI on cognition, structural Magnetic Resonance Imaging (MRI) measurements and patient reported outcomes.

Methods: Twenty MS patients with subjective and/or objective cognitive dysfunction were included in an open-label study in a dual center setting. The intervention consisted of a 8 week course of MBI that closely followed the MBSR program according to J. Kabat-Zinn. Study timepoints include a baseline assessment, post-intervention and 6 months follow-up. A pre-post analysis will be done. Outcome measures include change in cognitive function and change in perceived cognitive deficits. MRI gray matter volume and selected regions based on voxel-based morphometry will be analyzed. Other secondary outcome measures are patient reported outcome measures on quality of life, fatigue, anxiety and depression, coping and stress.  

Results: The study is ongoing with post-intervention measurements that will be finished in december 2017.

Conclusions: Preliminary results of the study comparing cognitive tests, questionnaires and MRI data before and after the MBI will be presented during the meeting.