Effects of a Weight Based Training Program on Bone Density, Cognition, and Quality of Life

Background: Osteopenia is a health risk in older adults and people with MS may be at risk. A contributing factor to the pathogenesis of osteopenia is the use of corticosteroids, commonly used to manage MS relapses. Weight-based training may be considered one method to reduce osteopenia, as well as a beneficial treatment in MS patient rehabilitation. This study aims to look at the effects of weight-based training on bone density, cognition, depression, and quality of life in MS patients.

Objectives: To examine the effects that a weight-based training program has on bone density, cognition, and quality of life in a clinical practice setting.

Methods: 25 patients were studied. They were between the ages of 45-55, had an EDSS <5.5, were capable of completing the bodyweight training regimen unassisted, and were diagnosed with Multiple Sclerosis. Participants were required to do a DEXA scan day 1 and at week 14 (+/- 2 weeks). Participants completed the workout once per week via zoom with physical therapist led instructional classes and twice a week at home unassisted. Patients were required to complete 6 weeks of the program; the final two weeks (7&8) were for make-up visits. SMDT and MSIS were performed at day 1, week 8 and week 12 (+/-2 weeks). Patients received an instructional video explaining the study and how to properly perform each exercise.

Results: The results showed a slight learning effect on the SDMT scores. Preliminary results for the MSIS and DEXA scan have not yet been analyzed as this study is ongoing. There were barriers to consider with regards to obtaining the date including inability to obtain results in person in favor of zoom due to the pandemic and other social and emotional factors.

Conclusions: This study was implemented to evaluate the effect of a simple set of body weight exercises over the course of 6 weeks and its effect on bone density, cognition and quality of life. Preliminary results show a slight learning effect based on the SDMT scores. DEXA scan T-scores and MSIS scores will be statistically analyzed and presented at the study’s conclusion.