Prevalence of Patient Self-Reported Sexual Dysfunction in Neuromyelitis Optica Spectrum Disorder

Background:  Sexual dysfunction in Multiple Sclerosis (MS) has been estimated as high as 63% with a male predominance. We may expect a higher prevalence in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD) due to associated spinal cord involvement. It may have a significant impact on quality of life.  Use of a questionnaire will open the discussion for better ways to assess the impact and physiological implications of sexual dysfunction symptoms in NMOSD. The Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19) could be an appropriate screening tool for sexual dysfunction symptoms in NMOSD.

Objectives:  To determine and assess the prevalence of patient self-reported sexual dysfunction related symptoms using the MSISQ-19 as screening tool in subjects with NMOSD and MS to increase awareness of this comorbidity among providers.

Methods:  This is a descriptive, questionnaire based cross-sectional study. A total of 60 patients with NMOSD and MS will be enrolled in each group. The Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19) will be administered during patient follow-up clinic visit to determine the patient's perceived sexual dysfunction. Demographic data and Expanded Disability Status Scale (EDSS) score will be analyzed as a method to quantifying disability.

Results:  This is an ongoing study in the process of data collection. Complete results and analysis will be presented at the conference. 

Conclusions:  Recognition of sexual dysfunction in patients with NMOSD may have a significant impact on their quality of life. Screening methods can lead to prompt treatment and appropriate patient referrals. MSISQ-19 may be a useful screening questionnaire for early detection of sexual dysfunction in NMSOD patients.