Patient-Reported Overactive Bladder in Neuromyelitis Optica Spectrum Disorder

Background: Bladder dysfunction may lead to urogenital symptoms that may have a significant impact on a patient’s quality of life. Overactive bladder is one of the most disturbing and it can be present in approximately 80% of patients diagnosed with Multiple Sclerosis (MS). Correlation between the degree of spinal cord involvement and severity of symptoms has been described in MS. However, the association between Neuromyelitis Optica Spectrum Disorder (NMOSD) and overactive bladder has not been completely described, leading to unawareness and lack of treatment of this associated comorbidity.

Objectives: To determine and compare the prevalence of patient self-reported overactive bladder related symptoms in subjects with NMOSD and MS to increase awareness of this comorbidity among providers.

Methods: This is a descriptive, questionnaire based cross-sectional study. A total of 60 patients with NMOSD and MS will be enrolled in each group. Overactive Bladder Assessment Questionnaire will be administered during patient follow-up clinic visit. Demographic data and Expanded Disability Status Scale (EDSS) score will be analyzed as a method to quantifying disability.

Results: This is an ongoing study in the process of data collection. Complete results and analysis will be presented at the conference. 

Conclusions: Overactive bladder is one of the most disturbing symptoms and can have significant impact on the quality of life of patients with demyelinating diseases. Methods for early diagnosis can lead to prompt treatment and appropriate urologic referrals. OAB Assessment Tool may be a useful screening questionnaire for early detection in patients with NMSOD.